A20 Controls Macrophage to Elicit Potent Cytotoxic CD4+ T Cell Response
نویسندگان
چکیده
منابع مشابه
A20 Controls Macrophage to Elicit Potent Cytotoxic CD4+ T Cell Response
Emerging evidence indicates that CD4(+) T cells possess cytotoxic potential for tumor eradication and perforin/granzyme-mediated cytotoxicity functions as one of the important mechanisms for CD4(+) T cell-triggered cell killing. However, the critical issue is how the cytotoxic CD4(+) T cells are developed. During the course of our work that aims at promoting immunostimulation of APCs by inhibit...
متن کاملCan Levamisole Upregulate the Equine Cell Mediated Macrophage (M1) Dendritic Cell (DC1) CD4 T-helper 1 (Th1) CD8 T-cytotoxic 1 (Tc1) Immune Response in Vitro?
Equine Protozoal Myeloencephalitis (EPM) is arguably the most common and costly equine neurologic diseases nationwide. The national seroprevalence is >50%, but only 0.5-1% of all horses develops disease during their lifetimes. Some EPM affected horses have decreased immune response. A cell-mediated immune response has been shown to be protective for development of EPM after infection with Sarco...
متن کاملModeling the cytotoxic T cell response
OF DISSERTATION Submitted in Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy Computer Science The University of New Mexico Albuquerque, New Mexico
متن کاملCytotoxic T-cell response to respiratory syncytial virus in mice.
The role of the humoral and cellular arms of the immune response in protection against respiratory syncytial virus (RSV) infection and in the pathogenesis of the severe forms of this disease is poorly understood. The recent demonstration that some inbred mouse strains can be infected with RSV has opened the way to a detailed investigation of RSV immunity. We report here the finding of major his...
متن کاملCD4 Effector T Cell Subsets in the Response to Influenza
The immune response of naive CD4 T cells to influenza virus is initiated in the draining lymph nodes and spleen, and only after effectors are generated do antigen-specific cells migrate to the lung which is the site of infection. The effector cells generated in secondary organs appear as multiple subsets which are a heterogeneous continuum of cells in terms of number of cell divisions, phenotyp...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: PLoS ONE
سال: 2012
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0048930